Depression May Be Early Warning Sign of Brain Changes, Study Finds
"Declining mood and worsening depressive symptoms in aging are associated with an increased risk of going on to develop Alzheimer’s disease dementia. Higher tau levels also predicted higher scores on the depression questionnaires in this group.Notably, none of these patterns appeared in participants who had already been diagnosed with mild cognitive impairment or Alzheimer's disease. "Getting a better understanding of the affective and behavioral changes in aging and neurodegenerative disease can potentially help us prepare for and better manage these symptoms as they appear."ReferenceMarkova, T.
- ▪"Declining mood and worsening depressive symptoms in aging are associated with an increased risk of going on to develop Alzheimer’s disease dementia.
- ▪Higher tau levels also predicted higher scores on the depression questionnaires in this group.Notably, none of these patterns appeared in participants who had already been diagnosed with mild cognitive impairment or Alzheimer's disease.
- ▪"Getting a better understanding of the affective and behavioral changes in aging and neurodegenerative disease can potentially help us prepare for and better manage these symptoms as they appear."ReferenceMarkova, T.
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| Original publisher | Newsweek |
| Canonical URL | https://www.newsweek.com/depression-may-be-early-warning-sign-of-brain-changes-study-finds-12365335 |
| Publication time | Wed, 26 Aug 2026 04:10:27 -0400 |
| Retrieval time | 2026-08-26T08:58:33.733Z |
| Last seen | 2026-08-26T08:58:33.733Z |
| Headline source | Publisher (no WeSearch rewrite) |
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| Summary | WeSearch · cerebras-chat (WeSearch summarizer) |
| Summary source text | contentText |
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| Substitutes article? | No — link-out required for full text |
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| Retrieval / RAG | May the content be exposed for third-party retrieval-augmented generation? | Not asserted |
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| Commercial reuse | May the content be reused commercially? | Not permitted |
Basis: Derived from the published RSS/Atom feed. Contact: [email protected]. Reviewed: 2026-07-24.
Opening excerpt (first ~120 words) tap to expand
By Melissa Fleur AfsharReporter0ShareNewsweek is a Trust Project memberSee more of our trusted coverage when you search.Prefer Newsweek on Googleto see more of our trusted coverage when you search.Rising levels of a protein tied to Alzheimer's disease may show up as depression years before memory problems set in, according to a new study that suggests changes in mood could serve as an early warning sign of brain deterioration in older adults.The research, published in The Journal of Neuroscience, found that as levels of a protein called tau increased in cognitively healthy older people, so did their depressive symptoms.
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Excerpt limited to ~120 words for fair-use compliance. The full article is at Newsweek.
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