Engineering enzymes with potential against ALS and Parkinson's disease
In an advance that could one day lead to new treatments for neurodegenerative diseases, Meredith Jackrel, an associate professor of chemistry in Arts & Sciences at Washington University in St. Louis, and her team have developed a method to rapidly produce and screen a class of disaggregase enzymes that can break down the misfolded proteins associated with ALS and Parkinson's disease.
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June 13, 2026 Engineering enzymes with potential against ALS and Parkinson's disease by Chris Woolston, Washington University in St. Louis edited by Lisa Lock, reviewed by Robert Egan Lisa Lock Scientific Editor Meet our editorial team Behind our editorial process Robert Egan Associate Editor Meet our editorial team Behind our editorial process Editors' notes This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility: fact-checked peer-reviewed publication trusted source proofread The GIST Add as preferred source Graduate student Madalyn Bochantine (right) and Meredith Jackrel discuss results in Jackrel's chemistry lab at WashU.
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