House Dust Mite Immunotherapy May Prevent Allergies in Kids
A study in Austria found that preventive sublingual immunotherapy (SLIT) for house dust mite allergens can induce immune responses in preschool children who are sensitized but not symptomatic. The treatment led to increased levels of blocking antibodies and reduced skin reactivity compared to a placebo. This suggests that early intervention may help prevent the development of allergies in young children.
- ▪Researchers assessed the effects of HDM-SLIT on preschool children aged 3-5 years who were sensitized to house dust mite allergens but did not show allergy symptoms.
- ▪Children receiving HDM-SLIT showed significantly greater increases in Der p1-specific IgG levels compared to those receiving placebo over 24 months.
- ▪Fewer children treated with HDM-SLIT became polysensitized compared to the placebo group, and no serious treatment-related adverse events were reported.
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TOPLINE:In preschool children who were sensitized to house dust mite (HDM) allergens but did not have any allergy symptoms, preventive sublingual immunotherapy (SLIT) induced blocking antibodies, reduced skin and basophil reactivity, limited new sensitizations, and was well tolerated.METHODOLOGY:Researchers in Austria assessed whether preventive HDM-SLIT modulated immune responses in sensitized but symptom-free preschool children aged 3-5 years.They randomly assigned children to receive either daily HDM-SLIT (300 index of reactivity) or placebo and assessed those treated for more than 4 months.
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Excerpt limited to ~120 words for fair-use compliance. The full article is at Medscape.
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