IISc researchers decode how a virus hijacks host protein machinery
Instead, they hijack the host’s protein-making machinery, specifically ribosomes and translational factors.Viral multiplication“This process is essential for viral multiplication and infection. Hussain’s lab and the first author, devised a pulldown strategy using an EMCV IRES-containing mRNA to isolate the EMCV IRES pre-initiation complex from the cell lysate of rabbit reticulocytes (immature red blood cells). Cryo-EM grids frequently failed to yield enough particles for a reliable structure, but we persisted,” Prof.
- ▪Instead, they hijack the host’s protein-making machinery, specifically ribosomes and translational factors.Viral multiplication“This process is essential for viral multiplication and infection.
- ▪Hussain’s lab and the first author, devised a pulldown strategy using an EMCV IRES-containing mRNA to isolate the EMCV IRES pre-initiation complex from the cell lysate of rabbit reticulocytes (immature red blood cells).
- ▪Cryo-EM grids frequently failed to yield enough particles for a reliable structure, but we persisted,” Prof.
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Researchers at the Indian Institute of Science (IISc) in Bengaluru have decoded how the encephalomyocarditis virus (EMCV) hijacks a host’s protein synthesis machinery.EMCV is a rodent-borne animal virus that causes heart and brain inflammation, reproductive problems, and neurological disorders in many mammals.According to the researchers, viruses lack their own molecular machinery required for protein synthesis. Instead, they hijack the host’s protein-making machinery, specifically ribosomes and translational factors.Viral multiplication“This process is essential for viral multiplication and infection.
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