Impaired Spirometry Pattern Tied to Asthma Exacerbations
TOPLINEPatients with asthma and preserved ratio impaired spirometry (PRISm) experienced severe acute exacerbations more than twice as often as those with normal lung function. It was published online on July 17 in Journal of Asthma and Allergy.LIMITATIONSThe single-center retrospective study design and inclusion of a Japanese population could limit generalizability. PRISm classification was based on spirometry at a single timepoint, and treatment intensity could not be objectively defined as a covariate, potentially leaving residual confounding.DISCLOSURESNo specific funding was reported.
- ▪TOPLINEPatients with asthma and preserved ratio impaired spirometry (PRISm) experienced severe acute exacerbations more than twice as often as those with normal lung function.
- ▪It was published online on July 17 in Journal of Asthma and Allergy.LIMITATIONSThe single-center retrospective study design and inclusion of a Japanese population could limit generalizability.
- ▪PRISm classification was based on spirometry at a single timepoint, and treatment intensity could not be objectively defined as a covariate, potentially leaving residual confounding.DISCLOSURESNo specific funding was reported.
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TOPLINEPatients with asthma and preserved ratio impaired spirometry (PRISm) experienced severe acute exacerbations more than twice as often as those with normal lung function. This exacerbation burden was comparable to that seen in patients with obstructive ventilatory defects, despite the absence of overt airflow obstruction.METHODOLOGYResearchers conducted a retrospective analysis of 1411 adult patients with asthma in Japan.Based on spirometry, patients were categorized into control (normal % forced expiratory volume in 1 second [FEV1] and preserved FEV1/forced vital capacity [FVC], n=1102), PRISm (reduced %FEV1 with preserved FEV1/FVC, n=133), and airflow obstruction (reduced %FEV1 and reduced FEV1/FVC, n=176).Primary outcomes included the frequency of severe acute exacerbations…
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