Low Natriuretic Peptide Levels in Obesity? HF Risk Persists
A recent study found that adults with obesity often have lower levels of NT-proBNP, which may lead to missed diagnoses of heart failure. Despite NT-proBNP levels below the standard threshold, these individuals exhibited higher odds of heart failure symptoms and structural heart abnormalities. The findings suggest that NT-proBNP levels may not effectively rule out heart failure in obese patients.
- ▪The study included 2498 adults aged 50 years or older, with a significant portion classified as having obesity.
- ▪Adults with obesity and NT-proBNP levels below 125 pg/mL were more likely to show signs of heart failure compared to lean adults.
- ▪Each 5-unit increase in BMI was linked to a decrease in NT-proBNP levels by 46.9 pg/mL.
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TOPLINE:Adults with obesity had lower levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP), and many with NT-proBNP levels below the usual rule-out threshold (125 pg/mL) had higher odds of signs and symptoms of heart failure (HF) and structural heart abnormalities than lean adults with NT-proBNP levels ≥ 125 pg/mL.METHODOLOGY:Researchers used data from a Portuguese cross-sectional study (PORTHOS, 2022-2023) to assess how common measures of adiposity were linked to NT‑proBNP levels and whether standard NT-proBNP cutoffs missed HF in people with obesity.They included 2498 adults aged 50 years or older (60.2%-64.6% women). Adults advanced to detailed assessments if the screening NT-proBNP level was ≥ 125 pg/mL or if they reported a prior diagnosis of HF.
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