Pediatric Ketamine Sedation Not Tied to Serious AEs
A systematic review of 67,871 children receiving intravenous ketamine for procedural sedation found that serious adverse events were extremely rare. The study reported a sentinel event rate of 0.0087%, with no deaths or permanent neurologic deficits. These findings support the safety of ketamine use in pediatric emergency care.
- ▪The pooled frequency of sentinel events during pediatric ketamine sedation was 0.0087%.
- ▪Sentinel events were more common in children older than 10 years and those with upper respiratory infections.
- ▪The study found no deaths or permanent neurologic deficits associated with ketamine sedation.
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| Original publisher | Medscape |
| Canonical URL | https://www.medscape.com/viewarticle/pediatric-ketamine-sedation-not-tied-serious-adverse-events-2026a1000hxu?src=rss |
| Publication time | Fri, 29 May 2026 06:08:18 EDT |
| Retrieval time | 2026-05-29T10:20:00.361Z |
| Last seen | 2026-05-29T10:20:00.361Z |
| Headline source | Publisher (no WeSearch rewrite) |
| Excerpt source | publisher body |
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| Summary | WeSearch · cerebras-chat (WeSearch summarizer) |
| Summary source text | contentText |
| Citation coverage | Summary is a WeSearch-generated derivative; primary citation is the original publisher URL. |
| Cluster | AtaZVrWzBtyj |
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| Ranking reason | Story pages are not engagement-ranked. Hub feeds use recency, with optional source-diversified chronological ordering (cap consecutive stories per source). No personalized ranking. |
| Publisher visit | Yes — open original |
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| Snippet | May a short excerpt of the publisher's text be shown? | Allowed |
| AI summary | May WeSearch generate its own short summary of the article? | Limited |
| Retrieval / RAG | May the content be exposed for third-party retrieval-augmented generation? | Not asserted |
| Model training | May the content be used to train AI models? | Not asserted |
| Commercial reuse | May the content be reused commercially? | Not permitted |
Basis: Derived from the published RSS/Atom feed. Contact: [email protected]. Reviewed: 2026-07-24.
Opening excerpt (first ~120 words) tap to expand
TOPLINE:A systematic review including 67,871 children found that serious adverse events during intravenous ketamine procedural sedation in the emergency department (ED) were extremely rare, supporting the overall safety of ketamine use in pediatric emergency care.METHODOLOGY:Researchers conducted a systematic review of 20 studies including 67,871 individuals younger than 21 years who received intravenous ketamine for procedural sedation in EDs.From each study, they determined the frequency of airway and respiratory adverse events (airway obstruction, apnea, laryngospasm, and oxygen desaturation) as well as vomiting and recovery agitation.The primary outcome was a composite of serious adverse events, including sentinel events (life-threatening events such as tracheal intubation,…
Excerpt limited to ~120 words for fair-use compliance. The full article is at Medscape.
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