Researchers look at biomarkers which can predict dengue severity
Dengue has always remained one of the challenging tropical diseases because of the disease’s propensity to suddenly worsen when the patient is apparently recovering. In dengue-endemic regions, this will help the health systems optimise their health resources,” says Agiesh Kumar B, who is leading the IAV research into dengue biomarkers“Plasma leakage is a hallmark process in dengue viral infection that occurs due to the loss of vascular integrity in endothelial cells. Targeting endothelial markers released by activated endothelial cells could serve as effective biomarkers,” he added.“In the pilot study, around 150 dengue patients were screened at three points — on admission, at critical phase and during recovery stage.
- ▪Dengue has always remained one of the challenging tropical diseases because of the disease’s propensity to suddenly worsen when the patient is apparently recovering.
- ▪In dengue-endemic regions, this will help the health systems optimise their health resources,” says Agiesh Kumar B, who is leading the IAV research into dengue biomarkers“Plasma leakage is a hallmark process in dengue viral infection that o
- ▪Targeting endothelial markers released by activated endothelial cells could serve as effective biomarkers,” he added.“In the pilot study, around 150 dengue patients were screened at three points — on admission, at critical phase and during
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Dengue has always remained one of the challenging tropical diseases because of the disease’s propensity to suddenly worsen when the patient is apparently recovering. Clinicians cannot reliably predict which of the patients with apparently uncomplicated dengue will suddenly take a turn for the worse and go into haemorrhagic shock.Even though the WHO recommends the monitoring of certain red flags or critical signals such as persistent vomiting, abdominal pain, mucosal bleeding from the nose or gums, lethargy, these warning signs usually appear only after the underlying pathological process has been set in motion.In the last two decades, much global research has gone into understanding and identifying biomarkers (measurable biological indicators) that can predict complications of dengue…
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