San Francisco streets are reeling from deadly drug 20x more powerful than fentanyl
San Francisco is facing a crisis due to a new drug called isotonitazene, or ISO, which is twenty times more potent than fentanyl. Health officials have reported that ISO has already claimed lives and is being mixed with other synthetic opioids, making it even more dangerous. The Drug Enforcement Administration has issued warnings about the rising popularity of ISO and its potential to cause fatal overdoses.
- ▪ISO is twenty times more potent than fentanyl and has been linked to overdose deaths in San Francisco.
- ▪The drug is often undetectable in standard tests for fentanyl, increasing its danger.
- ▪Health officials are alarmed by the rising popularity of ISO among users in the Tenderloin district.
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Metro San Francisco streets are reeling from deadly drug 20x more powerful than fentanyl By Ben Chapman Published June 5, 2026, 8:03 p.m. ET See more of our coverage in your search results. Add The California Post on Google The streets of San Francisco are awash with a new drug called ISO that’s twenty times more potent than deadly fentanyl – and officials are sounding the alarm. The killer counterfeit opioid isotonitazene – known on the streets as ISO – claimed its first life in the drug-ravaged city in April, San Francisco Health Department officials said in an alert issued that month. San Francisco health officials said ISO was blended with another synthetic opioid called cychlorphine in the overdose death announced April 23.
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