‘Smart’ Nanoparticles Deliver mRNA Directly to Tumors in New Cancer Therapy
Researchers at the University of Adelaide have developed a targeted mRNA therapy using smart nanoparticles to reprogram immune cells within tumors. This approach specifically targets tumor-associated macrophages to restore their ability to recruit T cells and fight cancer. Early mouse trials showed significant reductions in tumor growth and immunosuppressive markers without detected side effects in other organs.
- ▪The study, published in Science Advances, utilizes smart nanoparticles studded with antibodies to deliver mRNA specifically to tumor-associated macrophages.
- ▪The mRNA instructs the macrophages to produce CXCL9, a chemical signal that recruits T cells to attack the tumor.
- ▪In mouse models with aggressive breast cancer, the treatment increased CXCL9 concentration by four times and reduced immunosuppressive macrophages by 63 percent.
- ▪The therapy was also tested in combination with immune checkpoint inhibitors, which led to increased T-cell diversity in tumors and lymph nodes.
- ▪Researchers noted that while no negative effects were observed in other organs, further safety studies are required before human trials can commence.
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| Publication time | Wed, 16 Sep 2026 08:30:00 +0000 |
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Javier CarbajalScienceSep 16, 2026 4:30 AM‘Smart’ Nanoparticles Deliver mRNA Directly to Tumors in New Cancer TherapyThe treatment can reprogram immune cells that have been corrupted by the cancer, strengthening the body’s ability to attack.Photograph: SCIEPRO/SCIENCE PHOTO LIBRARY/Getty ImagesCommentLoaderSave StorySave this storyCommentLoaderSave StorySave this storyOur immune systems don’t just fight bacteria and viruses invading the body. They are responsible for keeping our own tissues in check, taking out cancerous cells before they have a chance to grow.
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