USC scientists discover a hidden Alzheimer’s trigger and a possible way to shut it down
USC researchers have discovered new compounds that may help reduce brain inflammation associated with Alzheimer's disease. These compounds target an enzyme called cPLA2, which is linked to the risk of Alzheimer's, particularly in individuals with the APOE4 gene. The findings suggest that selectively inhibiting cPLA2 could be a promising strategy for treating neurodegenerative disorders.
- ▪Researchers at USC have identified compounds that may block brain inflammation tied to Alzheimer's disease.
- ▪The compounds target the enzyme cPLA2, which is linked to increased Alzheimer's risk in APOE4 gene carriers.
- ▪In mouse studies, one cPLA2 inhibitor successfully crossed the blood-brain barrier and influenced neuroinflammatory pathways.
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Science News from research organizations USC scientists discover a hidden Alzheimer’s trigger and a possible way to shut it down Researchers have discovered promising compounds that may block a key source of brain inflammation tied to Alzheimer’s disease. Date: May 26, 2026 Source: Keck School of Medicine of USC Summary: USC researchers have identified potential new drug compounds that may reduce the brain inflammation linked to Alzheimer’s disease, especially in people with the high-risk APOE4 gene. The compounds target cPLA2, an enzyme that seems to fuel harmful inflammation while also being important for normal brain activity.
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