Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function
A clinical trial investigated the effects of aspirin, acetaminophen, and ibuprofen on immune function in rhinovirus-infected volunteers. The study found that both aspirin and acetaminophen suppressed the serum neutralizing antibody response and increased nasal symptoms. There were no significant differences in viral shedding among the groups, but a trend towards longer shedding duration was noted in those taking aspirin and acetaminophen.
- ▪The trial involved sixty healthy volunteers who were infected with rhinovirus type 2.
- ▪Aspirin and acetaminophen were associated with a suppression of the antibody response and increased nasal symptoms.
- ▪No significant differences in viral shedding were observed, but a trend for longer duration was noted in the aspirin and acetaminophen groups.
Opening excerpt (first ~120 words) tap to expand
Clinical Trial J Infect Dis Actions Search in PubMed Search in NLM Catalog Add to Search . 1990 Dec;162(6):1277-82. doi: 10.1093/infdis/162.6.1277. Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function, viral shedding, and clinical status in rhinovirus-infected volunteers N M Graham 1 , C J Burrell, R M Douglas, P Debelle, L Davies Affiliations Expand Affiliation 1 Department of Community Medicine, University of Adelaide, South Australia. PMID: 2172402 DOI: 10.1093/infdis/162.6.1277 Item in Clipboard Clinical Trial Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function, viral shedding, and clinical status in rhinovirus-infected volunteers N M Graham et al. J Infect Dis. 1990 Dec.
…
Excerpt limited to ~120 words for fair-use compliance. The full article is at PubMed.
Discussion
0 commentsMore from PubMed
