Honeybee venom and melittin suppress growth in breast cancer (2020)
Research has shown that honeybee venom and its main component, melittin, can effectively suppress the growth of certain breast cancer subtypes. Specifically, these substances induce cell death in triple-negative and HER2-enriched breast cancers by inhibiting the activation of key growth factor receptors. This study highlights the potential of honeybee venom as a therapeutic agent in cancer treatment.
- ▪Honeybee venom and melittin induce cell death in aggressive breast cancer subtypes.
- ▪The venom suppresses activation of EGFR and HER2 receptors.
- ▪The study suggests potential therapeutic applications of honeybee venom in cancer treatment.
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NPJ Precis Oncol Actions Search in PubMed Search in NLM Catalog Add to Search . 2020 Sep 1:4:24. doi: 10.1038/s41698-020-00129-0. eCollection 2020. Honeybee venom and melittin suppress growth factor receptor activation in HER2-enriched and triple-negative breast cancer Ciara Duffy 1 2 3 4 , Anabel Sorolla 2 4 , Edina Wang 2 4 , Emily Golden 2 4 , Eleanor Woodward 2 4 , Kathleen Davern 4 5 , Diwei Ho 6 , Elizabeth Johnstone 4 7 8 , Kevin Pfleger 4 7 8 9 , Andrew Redfern 10 , K Swaminathan Iyer 5 , Boris Baer 11 , Pilar Blancafort 1 2 4 12 Affiliations Expand Affiliations 1 School of Human Sciences, The University of Western Australia, Perth, WA 6009 Australia. 2 Cancer Epigenetics Group, Harry Perkins Institute of Medical Research, Perth, WA 6009 Australia.
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