Genetic clue could lead to future Alzheimer’s treatments
The research relied heavily on mapping the folding of genomes, which are the genetic instructions of all living organisms.“Alzheimer’s disease cannot be understood one layer at a time,” said Jian Ma, a professor of computational biology at Carnegie Mellon University, who led the study. “The genome’s 3D structure is a fundamental regulatory layer that helps to connect DNA sequence to gene activity.
- ▪The research relied heavily on mapping the folding of genomes, which are the genetic instructions of all living organisms.“Alzheimer’s disease cannot be understood one layer at a time,” said Jian Ma, a professor of computational biology at
- ▪“The genome’s 3D structure is a fundamental regulatory layer that helps to connect DNA sequence to gene activity.
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(CN) — In a development that could shed light on potential treatment, researchers found Alzheimer’s disease appears to reshape how a patient’s genetic material is physically organized inside brain cells.In a study published Thursday in Science, researchers at Carnegie Mellon University’s School of Computer Science and the University of Pittsburgh School of Medicine discovered that the disease may involve changes in the three-dimensional organization of DNA inside brain cells.The research uncovers a previously underexplored aspect of Alzheimer’s disease biology that shows how genetic architecture is organized differently in certain brain cells of people with the disease.Researchers found that reorganization of the genome was linked to changes in genetic activity and in how brain cells were…
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