Vibe Medicine: Redefining Biomedical Research Through Human-AI Co-Work
With the emergence of large language models (LLMs) and AI agent frameworks, the human-AI co-work paradigm known as Vibe Coding is changing how people code, making it more accessible and productive. In scientific research, where workflows are more complex and the burden of specialized labor limits independent researchers and those in low-resource areas, the potential impact is even greater, particularly in biomedicine, which involves heterogeneous data modalities and multi-step analytical pipelines. In this paper, we introduce Vibe Medicine, a co-work paradigm in which clinicians and researchers direct skill-augmented AI agents through natural language to execute complex, multi-step biomedical workflows, while retaining the role of research director who specifies objectives, reviews intermediate results, and makes domain-informed decisions. The enabling infrastructure consists of three layers: capable LLMs, agent frameworks such as OpenClaw and Hermes Agent, and the OpenClaw medical skills collection, which includes more than 1,000 curated skills from multiple open-source repositories. We analyze the architecture and skill categories of this collection across ten biomedical domains, and present case studies covering rare disease diagnosis, drug repurposing, and clinical trial design that demonstrate end-to-end workflows in practice. We also identify the principal risks, such as hallucination, data privacy, and over-reliance, and outline directions toward more reliable, trustworthy, and clinically integrated agent-assisted research that advances research and technological equity and reduces health care resource disparities.
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Computer Science > Artificial Intelligence arXiv:2604.23674 (cs) [Submitted on 26 Apr 2026] Title:Vibe Medicine: Redefining Biomedical Research Through Human-AI Co-Work Authors:Zihao Wu, Steven Xu, Bowen Chen, Shaowen Wan, Yiwei Li, Wei Ruan, Yanjun Lyu, Siyuan Li, Dajiang Zhu, Tianming Liu, Lin Zhao View a PDF of the paper titled Vibe Medicine: Redefining Biomedical Research Through Human-AI Co-Work, by Zihao Wu and 10 other authors View PDF HTML (experimental) Abstract:With the emergence of large language models (LLMs) and AI agent frameworks, the human-AI co-work paradigm known as Vibe Coding is changing how people code, making it more accessible and productive. In scientific research, where workflows are more complex and the burden of specialized labor limits independent researchers and those in low-resource areas, the potential impact is even greater, particularly in biomedicine, which involves heterogeneous data modalities and multi-step analytical pipelines. In this paper, we introduce Vibe Medicine, a co-work paradigm in which clinicians and researchers direct skill-augmented AI agents through natural language to execute complex, multi-step biomedical workflows, while retaining the role of research director who specifies objectives, reviews intermediate results, and makes domain-informed decisions. The enabling infrastructure consists of three layers: capable LLMs, agent frameworks such as OpenClaw and Hermes Agent, and the OpenClaw medical skills collection, which includes more than 1,000 curated skills from multiple open-source repositories. We analyze the architecture and skill categories of this collection across ten biomedical domains, and present case studies covering rare disease diagnosis, drug repurposing, and clinical trial design that demonstrate end-to-end workflows in practice. We also identify the principal risks, such as hallucination, data privacy, and over-reliance, and outline directions toward more reliable, trustworthy, and clinically integrated agent-assisted research that advances research and technological equity and reduces health care resource disparities. Subjects: Artificial Intelligence (cs.AI) Cite as: arXiv:2604.23674 [cs.AI] (or arXiv:2604.23674v1 [cs.AI] for this version) https://doi.org/10.48550/arXiv.2604.23674 Focus to learn more arXiv-issued DOI via DataCite (pending registration) Submission history From: Zihao Wu [view email] [v1] Sun, 26 Apr 2026 12:27:25 UTC (2,578 KB) Full-text links: Access Paper: View a PDF of the paper titled Vibe Medicine: Redefining Biomedical Research Through Human-AI Co-Work, by Zihao Wu and 10 other authorsView PDFHTML (experimental)TeX Source view license Current browse context: cs.AI < prev | next > new | recent | 2026-04 Change to browse by: cs References & Citations NASA ADSGoogle Scholar Semantic Scholar export BibTeX citation Loading... BibTeX formatted citation × loading... Data provided by: Bookmark Bibliographic Tools Bibliographic and Citation Tools Bibliographic Explorer Toggle Bibliographic Explorer (What is the Explorer?) Connected Papers Toggle Connected Papers (What is Connected Papers?) Litmaps Toggle Litmaps (What is Litmaps?) scite.ai Toggle scite Smart Citations (What are Smart Citations?) Code, Data, Media Code, Data and Media Associated with this Article alphaXiv Toggle alphaXiv (What is alphaXiv?) Links to Code Toggle CatalyzeX Code Finder for Papers (What is CatalyzeX?) DagsHub Toggle DagsHub (What is DagsHub?) GotitPub Toggle Gotit.pub…
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