A Brain Implant for Depression Is About to Be Tested in Humans
Motif Neurotech has received FDA approval to begin human trials of a brain implant designed to treat severe, treatment-resistant depression. The device, implanted in the skull above the dura, targets the brain’s central executive network with wireless electrical stimulation. Patients will receive therapy at home using a charged baseball cap that communicates with the implant. The trial will assess safety, symptom reduction, and quality of life in about 10 participants over 12 months.
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Emily MullinScienceApr 27, 2026 1:02 PMA Brain Implant for Depression Is About to Be Tested in HumansWhile many brain-computer interface companies are focused on helping paralyzed people communicate, Motif Neurotech is targeting mental health disorders.Courtesy of MotifCommentLoaderSave StorySave this storyCommentLoaderSave StorySave this storyThe latest brain-computer interface could help people recover from severe depression. Motif Neurotech announced Monday that the US Food and Drug Administration has approved a human study to trial the company's blueberry-sized brain implant that sits in the skull and delivers electrical stimulation to treat depression.The Houston-based startup, founded in 2022, is part of a budding industry pursuing technology to read and interpret brain signals.
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